Biophysics and Evolutionary Genetics of Cell Division
Tuesday 8 June 2021, 16.00 hours
– Daniel Needleman, Professor of Molecular and Cellular Biology, Harvard University
Join the YouTube stream: [link will be announced later]
The spindle, the self-organizing structure that segregates chromosomes during cell division, shows remarkable diversity between species. I will present work from my lab in which we aim to integrate mechanistic and evolutionary studies of spindles. I will argue that evolutionary genetics provides a powerful approach to gain new mechanistic insights into spindles, and that the biophysics of spindle behaviors underlies many aspects of their changes over evolution. Taken together, our work provides a quantitative, mechanistic explanation for the variations in spindles over more than 100 million years of evolution.
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